Pharmaceutical Advanced Drug Delivery Systems & their Examples?

Here are some of the most advanced drug delivery systems and their examples:

1. *Nanoparticle-based delivery*: Tiny particles (1-100 nm) that can target specific cells or tissues.

- Example: Abraxane (paclitaxel-loaded nanoparticles for cancer treatment)

2. *Liposomal delivery*: Lipid-based vesicles that encapsulate drugs for targeted release.

- Example: Doxil (liposomal doxorubicin for cancer treatment)

3. *Polymeric drug delivery*: Biodegradable polymers that release drugs over time.

- Example: Gliadel (polifeprosan 20, a biodegradable polymer implant for brain cancer treatment)

4. *Microelectromechanical systems (MEMS)*: Tiny devices that release drugs in response to electrical signals.

- Example: MicroCHIPS (implantable device for osteoporosis treatment)

5. *Targeted delivery*: Drugs attached to antibodies or ligands that target specific cells or tissues.

- Example: Herceptin (trastuzumab, a monoclonal antibody for breast cancer treatment)

6. *Gene therapy*: Delivery of genetic material to cells to treat genetic disorders.

- Example: Luxturna (voretigene neparvovec, a gene therapy for inherited blindness)

7. *RNA-based delivery*: RNA molecules that silence or express specific genes.

- Example: Onpattro (patisiran, an RNA interference therapy for hereditary transthyretin amyloidosis)

8. *Microneedle-based delivery*: Tiny needles that deliver drugs through the skin.

- Example: MicronJet (microneedle-based device for influenza vaccination)

9. *3D printing-based delivery*: Customized pills or devices created using 3D printing technology.

- Example: Spritam (levetiracetam, a 3D-printed pill for epilepsy treatment)

10. *Implantable devices*: Devices implanted in the body to release drugs over time.

- Example: Norplant (levonorgestrel implant for contraception)

These advanced drug delivery systems offer improved efficacy, reduced side effects, and enhanced patient compliance.